Scarlet Spider

Scarlet Spider was the first spider-person before Spider-Man.

Ultimate Spider-Man
According to himself, Scarlet Spider was captured by Doctor Octopus and was subjected to many painful experiments by him. He was able to escape and forced to live in the sewers. Since then, Scarlet Spider held a personal vendetta against Dr. Octopus for what he did to him.

Trivia

 * Unlike most of his incarnations, who are actually clones, this Scarlet Spider is a human mutated with spider powers.
 * When the lower half of his mask is pulled up, it reveals he has a jawline similar to Spider-Man's.
 * Like his Ultimate comic book counterpart, Scarlet Spider's existence as a spider people was created by Doctor Octopus.
 * The Ben Reily version of the Scarlet Spider was alluded to by Flash Thompson, who temporarily used the Scarlet Spider name (shortly before turning into Agent Venom).