Rhino (Marvel)

Rhino (real name being Alexander O'Hirn) is one of Spider-man's toughest opponents. In Ultimate Spider-man he is a Midtown High School student turned rhinoceros mutant. In the upcoming Amazing Spider-Man 2, he is a escape convict that uses robotic Rhino suite.

Ultimate Spider-Man
Spider-Man and Power Man encounter Rhino at the burning Oscorp building and end up rammed into a tree by Rhino who makes off with some exotic animal-related chemicals. Spider-Man and Power Man later stakeout another Oscorp building and find Rhino charging towards an Oscorp train. Spider-Man and Power Man fight Rhino with the resulting fight causing Rhino to gash Power Man's leg. As Rhino charges towards Spider-Man, S.H.I.E.L.D. arrives causing Rhino to retreat with his "medicines." The next day, Peter Parker anticipates that Alex is responsible as Spider-Man sees Alex drink a chemical that transforms him into Rhino.

Spider-Man fights Rhino to keep him from attacking Flash Thompson while trying to reason with him. Spider-Man then works to protect Flash Thompson and not even Spider-Man's electro-webs could phase Rhino. When Spider-Man finds Flash Thompson at his house near a gas station, Spider-Man gets Flash Thompson away from the gas station when Rhino causes it to explode. Spider-Man tells Flash Thompson to call for help as he continues to fight Rhino. When Rhino starts charging towards Flash Thompson, Spider-Man tries to reason with Rhino while doing a bucking bronco move on him. In the nick of time, Power Man arrives and grabs Rhino by the horn. Spider-Man tells Flash that Rhino is actually Alex. Spider-Man traps Rhino on some oil as Spider-Man and Power Man double-team on Rhino enough to regress back to Alex O'Hirn.

As Alex is arrested by S.H.I.E.L.D., Flash Thompson apologizes to Alex as a female S.H.I.E.L.D. agent tells Flash that they'll take care of Alex. He was later turned back into the rhino juice-seeking Rhino by Octavius to be part of the Sinister Six in exchange for more serum and he fought Power Man, but was defeated by Nova and placed in a cell in S.H.I.E.L.D.'s new headquarters.