Martian Mastermind

The Martian Mastermind is the primary antagonist of the "Mars in Popular Culture" segment of Mars and Beyond

Mars and Beyond
In the program's description of a standard pulp science fiction story about Mars, the Martian Mastermind sends the Martian Robot to Earth to capture a human female, in this case, Miss Smith, the secretary of a scientist that is oblivious to the invasion. Upon being brought to Mars, Miss Smith begins making a desperate escape with the Mastermind in quick pursuit, eventually blowing him and the rest of his minions up with atomic cigarettes.

Mickey Mouse
The Martian Mastermind makes a cameo in "Roll 'em" as a monster in a science fiction film resembling Alien being shot at the studio.