101 Dalmatian Street is inspired by Dodie Smith's 1956 novel and Walt Disney's 1961 One Hundred and One Dalmatians, but it has been updated and moved to contemporary London. It depicts the adventures of the eldest Dalmatian siblings Dylan and Dolly, parents Doug and Delilah, and 97 younger puppies, all with names beginning with "D", who live all by themselves at the titular address. It is produced by London's Passion Animation Studios, written by Maria O'Loughlin, and directed by Miklos Weigert.
There is to be a total of 50 episodes, and each will run for ten minutes. The show was originally scheduled for release in fall 2018, but was delayed to 2019. The show did get a sneak peek preview on December 14, 2018, with the episode "Dog's Best Friend", "Boom Night", and "Merry Pups" on Disney Channel UK, Europe, Middle East, and Africa.
In early 2019, show writers have also announced that a second season is in the works.
In February of 2021, Atomic Cartoons said that another service studio would be working on Season Two, rather than them. 
During the Annecy Film Festival in 2018, details about the story of the show were announced. In modern day, the Twilight Bark has become a worldwide barking chain called the "World Wide Woof", and an American Dalmatian named Doug moves to London to become a fire dog, before meeting and marrying Delilah, a British Dalmatian who works as a nurse dog in a London hospital and is also one of the descendants of Pongo and Perdita.
The Dalmatian family live by themselves in a house in London, as their human owner is rich and lives on an island. Said human owner is said to be named after Dodie Smith. The home is full of wacky inventions to make the dogs' lives easier and are able to order whatever they need, with a running joke at how the house is a nightmare for the mailman.
The two Dalmatians both have their own litter of fifteen puppies from previous marriages, with their combined litters, another litter of fifteen and adoptions from strays or shelters adding up to 99 puppies.
Some of these puppies include:
- Dylan - One of the eldest, a pedantic Dalmatian puppy who dreams about being the first dog on Mars.
- Dolly - One of the eldest, a rebellious tomboy Dalmatian puppy who comes up with insane ideas.
- Dizzy & Dee Dee - A pair of mischievous Dalmatian puppies who are Dolly's sidekicks.
- Dawkins - A rather geeky Dalmatian puppy who is Dylan's underappreciated sidekick.
- Diesel - A silly Dalmatian puppy who loves to play in the dirt.
- Dante - A black Dalmatian puppy with white spots who is a bit of a goth. A bit paranoid and not the most positive pup, Dante constantly believes the world is coming to an end.
- Destiny, Dallas & Déjà Vu - A group of over the top Dalmatian puppy triplets dubbed the "Triple-D", each with their own collars and tags to tell them apart. Destiny wears hearts on her collar and tag, Dallas has diamonds on hers, and Déjà Vu has circles on hers. All three are media stars.
- Dimitri 1, 2 & 3 - Another group of Dalmatian puppy triplets often seen playing with each other. Each is told apart by the black fur patch on their eyes, the number of white sports on the left ear and gold chain.
- Delgado - A Dalmatian puppy who uses a wheelchair, and has a very charismatic personality. He is the fastest of his siblings.
- D.J. - A Dalmatian puppy who loves music and is often seen wearing headphones.
- Deepak - A Dalmatian puppy with a yin-yang coat who tries to keep calm.
- Da Vinci - An artistic Dalmatian puppy.
- Dorothy - The youngest of the Dalmatian puppies, who loves to chew on things.
Outside the Dalmatians, there are supporting characters:
- Clarissa, a snooty Corgi who lives next door to the Dalmatians.
- Arabella, one of Clarissa's entourage.
- Prunella, a pug who is one of Clarissa's friends.
- Portia, a poodle who Dylan has a crush on.
- Spencer, a sausage dog who is Portia's sidekick.
- Fergus, an Irish fox who is Dylan's best friend.
- Sid, a squirrel who has an obsession with nuts and is part of Fergus' Canal Crew.
- Big Fee, a rat who lives in the forest and is part of Fergus' Canal Crew.
- Roxy, a rottweiler who is Dolly's best friend.
- Snowball, a small, feisty Pomeranian dog, and friend of Dolly.
- Hansel, a husky whom Dolly has a crush on.
- Constantin, an Asian cat who lives next door to the Dalmatians, and is a mentor of Deepak.
- Hunter De Vil, a human boy who is the great nephew of Cruella De Vil.
- Pearl, a police horse.
- Godfrey, a guide dog.
- Doctor Dave, a doctor who has Delilah as an assistant at the hospital.
- Stanislav, who is Snowball's human and is the main merchant of Camden.
- A Cornish Doberman named Spike.
- Summer, a Cornish Border Collie.
- Bessie, a Cornish cow.
The show's initial antagonist was Hunter but the episode "London, We Have a Problem" reveals that Hunter is working for his great-aunt: Cruella De Vil, who returns as the main antagonist for the Season One climax multi-parter.
- Josh Brener as Dylan
- Michaela Dietz as Dolly
- Rhashan Stone as Doug
- Ella Kenion as Delilah
- Nefeli Karakosta as Dizzy
- Florrie Wilkinson as Dee Dee
- Rhys Issac-Jones as Dawkins
- Bert Davis as Diesel
- Kyle Soller as Dante
- Lauren Lindsey Donzis as Destiny and Déjà Vu
- Abigail Zoe Lewis as Dallas
- Jack Binstead as Delgado
- Maxwell Apple as D.J.
- Nikhil Parmar as Deepak
- Akiya Henry as Da Vinci and Roxy
- Margot Powell as Dorothy
- Aimee-Ffion Edwards as Arabella, Big Fee & Summer
- Harriet Carmichael as Clarissa the Corgi
- Bethan Wright as Prunella Pug
- Paloma Faith as Portia Poodle
- Ben Bailey-Smith "Doc Brown" as Sid the Squirrel and Spencer the Sausage Dog
- Conor Macniell as Fergus the Fox
- Rasmus Hardiker as Hansel the Husky
- Rufus Jones as Constantin the Cat
- Joshua LeClair as Hunter De Vil
- Tameka Empson as Pearl the Police Horse
- Daniela Denby-Ashe as Snowball the Pomeranian
- TBA as Godfrey the Guide Dog
- Michael D. Golab as Stanislav
- Michelle Gomez as Cruella De Vil
- Olly Murs as Spike the Cornish Doberman
- Miriam Margolyes as Bessie the Cornish Cow
- Stephen Mangan as Doctor Dave
- This is the twentieth 2D animated television series to be based on a Disney animated feature and/or its characters, after The New Adventures of Winnie the Pooh, TaleSpin, The Little Mermaid, Aladdin, Timon & Pumbaa, Jungle Cubs, 101 Dalmatians: The Series, Hercules, The Legend of Tarzan, Lilo & Stitch: The Series, The Emperor's New School, Stitch!, Jake and the Never Land Pirates, The 7D, The Lion Guard, Tangled: The Series, Stitch & Ai, Big Hero 6: The Series, and Legend of the Three Caballeros.
- This is also the second cartoon to be based on One Hundred and One Dalmatians, preceded by 101 Dalmatians: The Series back in the 1990s.
- This also makes One Hundred and One Dalmatians the fifth Disney franchise/film to have more than one television series based on the films of the franchise itself, the first four being The Jungle Book (TaleSpin and Jungle Cubs), Lilo & Stitch (which has three of them; Lilo & Stitch: The Series, Stitch!, and Stitch & Ai), The Lion King (Timon & Pumbaa and The Lion Guard), and Winnie the Pooh (Welcome to Pooh Corner, The New Adventures of Winnie the Pooh, The Book of Pooh and My Friends Tigger & Pooh).
- This is the second animated Disney show to air on all three main Disney Channels on cable television: Disney Channel, Disney Junior, and Disney XD; the first being The 7D.
- Unlike 101 Dalmatians: The Series, which was set in the United States, this series is based on the book and is set in the film's original location, London.
- According to the creators, only the events of the first animated 101 Dalmatians film happened in the show's timeline, meaning 101 Dalmatians II: Patch's London Adventure is non-canon in the "101 Dalmatian Street" continuity.
- This is one of the few series based on a Disney property not to be produced or involve Disney Television Animation in any way, as this series is fully produced by Atomic Cartoons and Passion Animation Studios. It is also one of the few European co-productions in which Disney is involved so far.
- The majority of the voice cast are English natives who are participating in their first Disney related project. Many of them have actually worked together on television shows such as Thomas the Tank Engine and video games such as Xenoblade Chronicles.
- The opening intro features Dolly on a street trying to corral her siblings to follow her; behind her are four humans walking across the street, with one of them being barefoot. This is a pop culture reference to the famous Abbey Road image of the Beatles from the 1969 album of the same name.
- There were originally 26 half-hour episodes, but it changed into fifty 11-minute episodes. There is also going to be five 22-minute specials.
- "Double Z Creative Blog" (January 24, 2019).
- "Annecy: Disney Channels Unveils 101 Dalmatian Street, Gigantosaurus, Space Chickens In Space". Variety (June 13, 2017).
- "Disney TV Animation News Post". Tumblr (November 9, 2017).
- "Atomic Cartoon Season Two" (February 25, 2021).
- "One Of Us Review" (November 15, 2018).