- February 1 - Hannah Montana & Miley Cyrus: Best of Both Worlds Concert
- February 14 - Step Up 2: The Streets (Touchstone Pictures)
- March 7 - College Road Trip is released to negative reviews.
- May 16 - The Chronicles of Narnia: Prince Caspian
- June 27 - WALL-E is released to universal acclaim.
- August 1 - Swing Vote (Touchstone Pictures)
- September 26 - Miracle at St. Anna (Touchstone Pictures)
- October 3 - Beverly Hills Chihuahua is released to mixed reviews.
- October 17 - Morning Light
- October 24 - High School Musical 3: Senior Year and Roadside Romeo
- November 21 - Bolt is released to universal acclaim.
- December 25 - Bedtime Stories
- January 10 - The Little Mermaid opens on Broadway.
- January 12 - Mary Poppins closes in the West End after a three year run.
- June 27 - Pixar films begin using the current Walt Disney Pictures logo starting with WALL-E.
- December 8 - Disney announces to increase its ownership of Jetix Europe from 74% to 96%, and later eventually purchase the remainder of the company and have them delisted from the Euronext.
- December 24 - Walt Disney Pictures parts ways with Walden Media over the distribution of The Voyage of the Dawn Treader, the next film in the Chronicles of Narnia series, citing the weak box-office performance of Prince Caspian and an inability to come to a mutual agreement with Walden over the financial terms of the next film. (Dawn Treader would eventually be picked up by Fox in January 2009.)
- February 2 - Vivian Garcia-Shapiro
- February 4 - Baljeet Tjinder
- February 5
- February 8 - Vanessa Doofenshmirtz
- February 17 - Charlene Doofenshmirtz, Carl Karl
- February 22 - Balthazar Horowitz
- February 23 - Betty Jo Flynn, Clyde Flynn
- February 29 - Pinky the Chihuahua
- March 1 - Peter the Panda
- March 8 - Love Handel
- March 23 - Roger Doofenshmirtz
- April 19 - Norm
- May 24 - Suzy Johnson, Coltrane
- June 27 - WALL-E, EVE, GO-4, M-O, AUTO, Captain B. McCrea, Hal, John, Mary
- June 14 - Reginald Fletcher, Winifred Fletcher
- August 26 - Queen Athena, Marina Del Rey, Benjamin, The Catfish Club Band, Stevie, Electric Eels
- October 28 - Rosetta, Fawn, Silvermist, Iridessa, Clank, Bobble, Fairy Mary, Terence, Vidia, Queen Clarion
- November 21 - Bolt, Mittens, Rhino, Penny, Penny's Mom, Dr. Calico
- December 25 - Skeeter Bronson, Jill Hastings, Violet Nottingham, Aspen, Wendy Bronson, Patrick, Bobbi, Marty Bronson
- January 7 - Disney MGM Studios is renamed Disney's Hollywood Studios.
- January 8 - A portion of a parade float collapses in Tokyo Disneyland during "Disney Dreams on Parade". 24 performers and 1 guest are injured.
- January 31 - Disneyland Dream Suite opens at Disneyland.
- March 22 - Stitch Live! opens at Walt Disney Studios Park.
- April 15 - The Tokyo Disney Resort begins its 25th anniversary celebration.
- April 28 - It's a Small World opens at Hong Kong Disneyland.
- May 31 - Toy Story Midway Mania! opens at Disney's Hollywood Studios.
- June 17 - Toy Story Midway Mania! opens at Disney's California Adventure.
- July 8 - The Tokyo Disneyland Hotel opens at the Tokyo Disney Resort.
- September 27 - Pocahontas and her Forest Friends closes at Disney's Animal Kingdom.
- October 20 - Walt Disney Imagineering Blue Sky Cellar opens at Disney's California Adventure.
- January 26 - Mickey Mouse Clubhouse Season 2 premieres on Playhouse Disney.
- February 1 - Phineas and Ferb begins airing regularly on the Disney Channel.
- February 18 - Power Rangers Jungle Fury debuts and becomes the last Power Rangers series to air on Toon Disney and Jetix.
- September 6 - Imagination Movers premieres on Playhouse Disney and Stanley gets cancelled.
- September 26 - The Suite Life on Deck (the sequel to The Suite Life of Zack and Cody) premieres on the Disney Channel.
- September 27- My Friends Tigger & Pooh Season 2 premieres on Playhouse Disney.
- October 8 - Stitch! premieres on TV Tokyo and Disney Channel Japan.
- October 27 - Cars Toons: Mater's Tall Tales premieres.
- November 3 - Power Rangers Jungle Fury airs its final episode on Toon Disney through Jetix.
- November 8 - Tasty Time with ZeFronk premieres on Playhouse Disney.
- November 20 - The Emperor's New School airs its final episode.
- December 17 - A Muppets Christmas: Letters to Santa premieres on NBC.
- November - Gemstone Publishing loses the Disney comic license and stops publishing Walt Disney's Comics and Stories and Uncle Scrooge.
- January 31 - DuckTales: Scrooge's Quest
- March 6 - Walt Disney Treasures - Uncle Scrooge: A Little Something Special
- November 20 - DuckTales: The Gold Odyssey
- May 6 - Percy Jackson and the Olympians: Battle of the Labyrinth
- June 24 - Disney Lost and Found: Exploring the Hidden Artwork from Never-Produced Animation
- August 5 - Disney Channel Rocks!: A Companion to All Your Favorite Shows
- August 26 - Kingdom Keepers II: Disney at Dawn
- October 14 - Disney's Dogs
- February 5 - Turok
- February 26 - Disney Friends
- March 1 - Cars: Rev It Up In Radiator Springs for V.Smile
- April 4 - The Suite Life of Zack & Cody: Circle of Spies
- August 7 - Hannah Montana: Spotlight World Tour
- August 13 - The Cheetah Girls: Passport to Stardom
- October 21 - Disney Sing It
- November 7 - Disney TH!NK Fast for PlayStation 2
- November 8 - Kingdom Hearts coded is released only on mobile phones in Japan
- November 25 - Club Penguin: Elite Penguin Force
- December 2 - Kingdom Hearts Re:Chain of Memories is released in the United States
- December 18 - Disney TH!NK Fast for Wii
DVD and Blu-ray releases
- January 21 - The Game Plan
- January 28
- Hannah Montana: One in a Million
- Twitches Too: Double Charmed Edition
- February 5
- February 19
- March 4
- 101 Dalmatians: Platinum Edition
- My Friends Tigger & Pooh: Friendly Tails
- March 18 - Enchanted
- April 29 - Classic Caballeros Collection
- May 20
- National Treasure: Book of Secrets
- The Muppet Show: Season Three
- May 27
- June 10
- Home Improvement: The Complete Eighth Season and Final Season (Touchstone Television)
- Army Wives: The Complete First Season (ABC Studios)
- June 17
- July 15
- College Road Trip
- Step Up 2: The Streets: Dance-Off Edition (Touchstone Home Entertainment)
- July 29
- Phineas and Ferb: The Fast and the Phineas
- Wizards of Waverly Place: Wizard School
- August 5
- Little Einsteins: Flight of the Instrument Fairies
- Handy Manny: Manny's Pet Roundup
- August 12 - Mulan / Mulan II 3-Disc Collector's Set
- August 19
- August 26
- September 2
- Mickey Mouse Clubhouse: Mickey's Storybook Surprises
- My Friends Tigger & Pooh: Hundred Acre Wood Haunt
- Desperate Housewives: The Complete Fourth Season (ABC Studios)
- Eli Stone: The Complete First Season (ABC Studios)
- September 9
- Grey's Anatomy: The Complete Fourth Season (ABC Studios)
- Ugly Betty: The Complete Second Season (ABC Studios)
- September 16
- September 23
- Schoolhouse Rock!: Election Collection
- High School Musical 2: 2-Disc Deluxe Dance Edition
- Brothers & Sisters: The Complete Second Season (ABC Studios)
- Samantha Who?: The Complete First Season (ABC Studios)
- October 7
- October 14 - Little Einsteins: The Christmas Wish
- October 21 - Have Yourself a Goofy Little Christmas
- November 5
- Walt Disney Treasures: The Chronological Donald, Volume 4
- Dr. Syn, The Scarecrow of Romney Marsh
- November 11 - Scrubs: The Complete Seventh Season (ABC Studios)
- November 18
- Hannah Montana: Season 1
- Hannah Montana DVD Game
- High School Musical DVD Game
- December 2 - The Chronicles of Narnia: Prince Caspian
- December 9 - Lost: The Complete Fourth Season (ABC Studios)
- December 16
- December 30 - The Secret Life Of The American Teenager: Volume One (ABC Family)
- January 18 - Lois Nettleton (actress and voice actress)
- January 19 - Suzanne Pleshette (actress and voice actress)
- February 9 - Robert DoQui (actor)
- April 5 - Charlton Heston (actor and voice actor)
- April 14 - Ollie Johnston (animator)
- May 29 - Harvey Korman (actor and comedian)
- June 22 - George Carlin (stand-up comedian, actor, social critic, and author)
- July 4 - Thomas M. Disch (author and poet)
- July 22
- July 25 - Bruce Adler (actor, voice actor, and singer)
- August 9 - Bernie Mac (stand-up comedian, actor, and voice artist)
- August 30 - Steve Schatzberg (voice actor and singer)
- September 1 - Don LaFontaine (voice actor)
- September 26 - Paul Newman (actor, film director, producer, race car driver, IndyCar owner, entrepreneur, and activist)
- December 25 - Eartha Kitt (actress and singer)
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