The son of Midtown High teacher Spencer Smythe, Alistair was also a student of his father. When visiting Oscorp Tower on a field trip, Spencer insisted Alistair be paired with Harry Osborn, a former Midtown student who had joined the student group for his friend Peter Parker.
When the tour guide asked for volunteers to try out a two-manned robot, Alistair attempted to come forward, but Harry stopped him to suggest Peter and his trip partner Liz Allan went instead, much to Alistair's annoyance. He later applied to Osborn Academy for Geniuses, being accepted sometime later.
After Vulture was released from prison and given a teaching position at Osborn Academy, Norman Osborn told him to go to Horizon High to steal the V-252. He refused, however, Alistair volunteered to do it for him.
At the Stark Expo, Alistair, Vulture, and a few Osborn Academy students in Vulture suits tried to combat Ghost, but Ghost made their suits malfunction.