It is Lilo's birthday, but no one seems to remember. While she and Stitch hand out invitations for their own party, they encounter Gantu as well as an experiment that gives people amnesia. All three of them try to catch Amnesio, which causes them to lose their memories of each other. Now thinking that her name is Martha, Stitch is an escaped convict, and Gantu is her partner cop named Lenny, Lilo teams up with him to hunt down Stitch and find clues to their lost memories.
- Moral: Family means nobody gets forgotten.
- When Amnesio flies around in several instances, the song "Flight of the Bumblebee" is heard playing.
- The password which reverses Amnesio's mind-erasing effects is "ʻohana", a Hawaiian word that Jumba didn't know of until well after Amnesio's creation.
- The password could also be "family", but it works in any language.
- It is also possible that Jumba changed the password once he was already living on Kauai before the experiments were released onto the island.
- Nosox and Nodessertro were both mentioned by Hämsterviel in this episode, hinting that Gantu had likely captured them. However, while Nosox physically appeared in "Snafu", Nodessertro did not. It is possible that they either set him free because he was considered useless, or he managed to escape.
- This episode reiterates that Gantu apparently has a good side to him, as he became very kind at once while he was temporarily under Amnesio's effects.
- The arcade game Lilo/Martha was playing had sound effects similar to Galaga, while the game the boy was playing had audio effects similar to Street Fighter.
- Kixx, Sprout, and Poxy's holographic silhouettes appeared on Jumba's computer.
- Before Gantu/Lenny releases Amnesio, he sees a family of ducks and says, "I'm lost," a callback to the first film.
- This episode marks Cobra's first appearance in the series. He serves as a guest at Lilo's birthday party.