"And the Mole Rat Will Be CGI" is the sixty-fifth episode of Kim Possible, and also the last episode to air in the show's third season (though it chronologically takes place before Kim Possible Movie: So the Drama, which aired over a year earlier).
- Anneliese van der Pol (Heather) and Raven-Symoné (Monique) also work together on That's So Raven and Raven's Home.
- Anneliese Van Der Pol, who voices Heather in this episode, was originally offered the part of Kim, but she turned it down, allowing it to go to Christy Carlson Romano.
- Rufus' "CGI form" had a few things different from the original Rufus, barring just his clothes: he had proper hands, white eyes, a thicker tail and no claws.
- The squirrel suits that Kim and Ron wore in New Zealand are the same suits that they wore at the beginning of the episode, Bad Boy.
- A scene that was scripted but was cut from the final show had Rufus' reaction to his CGI counterpart.
- Ron just cannot get the actor portraying him to "Ron It Up", and say anything besides "Whatever".
- When Kim and Ron are saving the day from Junior, Ron's freckles are missing. But when he takes his helmet off, he has his freckles again.
- When Jimmy Blamhammer states, "We're shooting back-to-back sequels", it's a reference to the 1980s movie trilogy, Back to the Future. The second and third movies in that trilogy were filmed immediately after one another.
- The movie producer/director character Jimmy Blamhammer is based on filmmaker Jerry Bruckheimer.
- When Kim and Ron are in Bueno Nacho towards the end of the episode, Ron refers to the concept of a Kim Possible Movie as "Hollyweird". This is a reference to this being the intended final episode before the TV movie So The Drama.
- The episode's title and the plot seem to foreshadow the live-action remake that was released in 2019.