April 21

Theatrical releases

1995 - The Bill Nye the Science Guy episode "Waves" premieres in syndication.
2001 - The Lloyd in Space episode "Babysitter Lloyd" premieres on ABC.
2006
- The Emperor's New School premieres on Disney Channel with the episode "Peasant for a Day".
- The That's So Raven episode "Driving Miss Lazy" premieres on Disney Channel.
2008 - The Emperor's New School premieres on Disney Channel with the episode "Auction Action/The Astonishing Kuzco-Man".
2013 - The Once Upon a Time episode "Lacey" premieres on ABC.
2015 - The Agents of S.H.I.E.L.D. episode "The Frenemy of My Enemy" premieres on ABC.
2017 - The Tangled: The Series episode "Cassandra v. Eugene" premieres on Disney Channel.
2019 - The Star vs. the Forces of Evil episodes "A Boy and His DC-700XE" "The Monster and the Queen" and "Cornonation" premiere on Disney Channel.

1922 - Buddy Pepper (songwriter, composer, arranger, and actor)
1949 - Patti LuPone (actress and singer)
1951 - Tony Danza (actor, television personality, tap dancer, boxer, and teacher)
1958 - Andie MacDowell (model and actress)
1959 - Robert Smith (singer-songwriter, musician, and record producer)
1961 - Cathy Cavadini (actress, voice actress, and singer)
1970
- Nicole Sullivan (actress, voice actress, and comedian)
- Rob Riggle (actor, voice actor, comedian, and U.S. Marine)
1974 - John Hasler (actor and voice actor)
1979 - James McAvoy (actor and voice actor)
1983 - Gugu Mbatha-Raw (actress)
1995 - Thomas Doherty (actor)

1910 - Mark Twain (author writer, humorist, entrepreneur, publisher, and lecturer)
1978 - Thelma Boardman (voice actress and writer)
2016 - Prince (singer, songwriter, musician, and actor)
2018 - Verne Troyer (actor, comedian, YouTuber, and stunt performer)