In 2012, Agent Phil Coulson went to Stark Tower for help, but Tony Stark excused himself, saying he was on a date with Pepper Potts. At first he was reluctant to help SHIELD, but with some insistence of Pepper, he agreed to help. Loki uses the Stark tower as the location to open the portal that allowed the entry of the Chitauri to Earth. While the invasion took place Loki remained in the Tower until Thor appeared, which led to a fight between the two brothers. As Thor surpassed him in power, Loki decided to jump from the tower and fled in a Chitauri vehicle. Loki fell back to the tower after he caught an explosive arrow of Hawkeye. At the Tower, he came across with Hulk, who gave him a beating. While the others Avengers fought against the Chitauri, Black Widow climbed the tower and with the help of Erik Selvig was able to close the portal (after Stark put a nuclear bomb into the Chitauri Space). When Loki was recovering from the beating, he saw that he was surrounded by the Avengers. The tower was almost destroyed during the invasion, the only letter of the word stark was the letter A as reference to the Avengers.
In 2014, having been repaired and renamed to Avengers Tower, Avengers Tower appears briefly during a targeting sequence. Months later, the Avengers returned from Sokovia after a successful mission as they had recovered Loki's scepter and captured Baron von Strucker. In honor of that victory, Stark decided to organize a party in which they were attacked by the Iron Legion led by Ultron. Days later, Captain America and Iron Man fought because Stark sought to use the android that Ultron had created. Rogers and Maximoff twins efforts twins were in vain as Thor using his Mjolnir gave life to synthetic android. Thor explained to them that Stark was right because "Vision" was the only one able to defeat Ultron. Vision won the confidence of the Avengers lifting Mjolnir before leaving to Sokovia and stop Ultron for the last time.
- It occupies the same location as the MetLife Building.