Ben and Me opens with two tour groups simultaneously visiting a statue of Benjamin Franklin. The human tour group discusses Franklin's life and achievements, while the leader of a mouse tour group reveals the contributions of a mouse, Amos, to Franklin's career.
Narrated by Amos, through his memoirs, the mouse recalls how he first met and befriended Benjamin Franklin, eventually aiding in his publishing, inventions, and political career. Amongst Amos' contributions were bifocals, inspiring Franklin to build the stove, and changing the format of Poor Richard's Almanac to an event-oriented newspaper, the Pennsylvania Gazette. After Ben's experiments with electricity unintentionally endanger Amos' life, Amos leaves Ben and moves back in with his family. Years later, Amos hears of Franklin again when he read from the newspaper that the inventor was sent to England as part of a colonial attempt to reason with the king over the unfair taxations imposed on the colonies. The mission is a failure, as Franklin says on his return, "The King was unreasonable. He wouldn't listen." Amos, seeing this- and the confusion and anger of the colonists- realizes he could help, but initially refuses. Amos and Franklin finally resolve their disagreements in the midst of the American Revolution, and in the end, Amos plays a key but little-known role in aiding Thomas Jefferson with the drafting of the Declaration of Independence.
Deleted scenes (extended version of the animated short film)
Some prints of this cartoon are missing scenes telling about Amos Mouse's family. These sequences were created for the short's presentation in the Disneyland episode, "The Liberty Story", and even on Mouseterpiece Theatre and later the extended version released on the Walt Disney Mini Classics line of videos. Also seen on UK VHS of Walt Disney's Fables Volume 3.
- Christopher Mouse and his family of 24 moved to London from Devonshire and settled in the cellar of bakery on Fleet Street. While Christopher gathering flour in the sack, he is caught by a fat cat (resembling Lucifer from Cinderella) he blows the flour to the cat and chased Christopher, until he made it in the cellar.
- Arrowdus Mouse sails through Thames River in a teacup.
- Aloysius Mouse working as a painter under the tutelage of famous German painter Hans Holbein.
- Jason Mouse, Amos' great-great-great-grandfather, fighting for the mice's rights and moved with his family onboard the ship Mayflower to the new land America called Plymouth Colony in Plymouth, Massachusetts.
- Sterling Holloway as Amos (Narrator)
- Charles Ruggles as Benjamin Franklin
- Hans Conried as Thomas Jefferson/Thief
- Bill Thompson as Governor Keith/Creditor/Parrot/Tour Guide
- Stan Freberg as Mouse Tour Guide
- Disneyland, episode #3.25: "The Liberty Story"
- Walt Disney's Wonderful World of Color, episode #11.8: "Ben and Me/Peter and the Wolf"
- The Mouse Factory, episode #2.9: "Ben Franklin"
- Walt Disney, episode #29.16: "Ferdinand the Bull and Mickey"
- Donald's Quack Attack, episode #94
- Walt Disney Treasures: Disney Rarities
- Walt Disney's Timeless Tales: Volume 3
- Walt Disney's Fables: Volume 3