- The title is a pun, as buds can be referencing friends or taste buds.
- Randy gains super senses in this episode.
- Howard's tongue photographing is a reference to Miley Cyrus's tongue snapshots.
- When Mcfist sets the device all the way it humorously tries to stop him with warnings: "med, high, seriously?, here we go.., all the way.."
- At the start of the episode The Creep can be seen at a taco stand called "taco no prisoners" which is a pun on the popular phrase "take no prisoners".
- This episode along with "Fudge Factory" are created in memory of Elaine Stritch in the credits.
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