For Disney, he played Eddie Valiant in the 1988 Touchstone Pictures film, Who Framed Roger Rabbit. His other roles include J. Edgar Hoover in Nixon, Johnny Scanlan in Passed Away, Mario in the 1993 Hollywood Pictures film, Super Mario Bros., Eddie Mannix in Hollywoodland, and Fezziwig and Old Joe in the 2009 animated film, A Christmas Carol, where he once again collaborated with director Robert Zemeckis.
Hoskins officially retired from show business in 2012 due to an ongoing battle with Parkinson's disease. He succumbed to pneumonia in 2014 at the age of 71 and was survived by his wife and 4 children.
- He was considered for the role of Wolverine in X-Men (2000) along with Russell Crowe, Glenn Danzig, Dougray Scott, Keanu Reeves, Gary Sinise, Mel Gibson, Aaron Eckhart, Jean-Claude Van Damme, Viggo Mortensen, and Edward Norton.
- He was nominated in 1989 for Best Actor in Who Framed Roger Rabbit but lost to Tom Hanks for BIG.