During World War II, Steve went with his partner Peggy Carter to Wakanda to warn King T'Chanda of a deal that would be between Hydra and the Shadow Council. Captain America, Peggy, and the King travelled to Morocco, where the meeting was being held, only to fall into an ambush and be taken to a castle in Switzerland. Peggy released Cap, and he chased after Heinrich Zemo while Peggy was able to defeat Arnim Zola. Rogers defeated Zola, and the Wakandan artifact T'Chanda was looking for was lost.
Captain America was one of the Avengers who flew off into space to help out Star-Lord. While there, the heroes were ambushed by the Klyntar symbiotes that had been reported by the Guardians of the Galaxy, one of which bonded with Captain America. Once back on Earth, the symbiote-infused heroes battled Spider-Man, Ironheart, Spy-D, Hulk and Doctor Strange, passing the alien infection on to many of them in the process. Captain America, the Avengers, and the rest of the infected New Yorkers were eventually freed after Spider-Man and Max Modell successfully infused Baby Groot with the Anti-Venom Symbiote, which in turn allowed Groot to cover the city with spores that destroyed the symbiote invaders.
