He is a master of disguise, using a special device to shift into various forms. However, much like the other villanous Marvel shapeshifter, Mystique, he can only replicate appearances, not powers. He is one of Spider-Man's deadliest foes.
In Spider-Man, Chameleon impersonates Spider-Man and frames him for robbing a bank. He later helped Mysterio and HYDRA with Spider-Man's bounty. After disguising himself as J. Jonah Jameson and attacking the real Jameson, Spider-Man manages to defeat Chameleon, and Chameleon is later imprisoned in a prison that negates his shapeshifting technology.
In Spider-Man: Far From Home, he appears as one of Nick Fury's agents, although the possibility of him becoming a villain in a future movie remains.
Chameleon was created by Stan Lee and Steve Ditko.