Cuckoo Loca lives inside a cuckoo clock inside Minnie's bow shop. In the series, she is Minnie and Daisy's friend who often helps her friends with whatever is going on in the shop.
In "Cuckoo-Loca's Egg-Celent Adventure", she has to take care of a lost bird's egg while Minnie and Daisy look for its mother. In the end, she accidentally breaks open the egg, and as it turns out, it contains another cuckoo bird toy.
Like in Minnie's Bow-Toons, Cuckoo Loca also lives inside a cuckoo clock inside the office of the Happy Helpers (Minnie and Daisy). When the Happy Helpers are needed and went to the Happy Helper's Van (which transforms into Minnie's Car and Pink Thunder), Cuckoo Loca rides in too and helps the Happy Helpers when needed.
In "Happy Birthday Helpers!", Cuckoo Loca calculates the aim of the Birthday Cake towards to the birthday party and just in time in after Goofy's magic trick.
"Loca" is the Spanish word in female for "crazy". Her name is probably a reference to when people compare someone crazy with a cuckoo bird.