Cuckoo-Loca first appeared in Minnie's shop. She lives inside a cuckoo clock inside Minnie's bow shop. In the series, she is Minnie and Daisy's friend who often helps her friends with whatever is going on in the shop.
In "Cuckoo-Loca's Egg-Celent Adventure", she has to take care of a lost bird's egg while Minnie and Daisy look for its mother. In the end, she accidentally breaks open the egg, and as it turns out, it contains another cuckoo bird toy.
Like in Minnie's Bow-Toons, Cuckoo-Loca also lives inside a cuckoo clock inside the office of the Happy Helpers (Minnie and Daisy). When the Happy Helpers are needed and go to the Happy Helpers' Van (which transforms into Minnie's Car and Pink Thunder), Cuckoo Loca rides in too and helps the Happy Helpers when needed.
In "Happy Birthday Helpers!", Cuckoo-Loca calculates the aim of the birthday cake towards the birthday party just in time for the finale of Goofy's magic act.
"Loca" is the Spanish word in female for "crazy". Her name is probably a reference to when people compare someone crazy with a cuckoo bird.