When New York went under a powerful sleeping spell cast by Nightmare, Doctor Strange enlisted the help of Danny Rand, also known as Iron Fist. He questioned Iron Fist's choice in bringing Spider-Man with him. Doctor Strange explained to them that it was the work of Nightmare and claimed that faith had brought Spider-Man to be with them. Strange brought Spider-Man and Iron Fist to the Dream World to stop Nightmare. Doctor Strange fought against Nightmare, his horse Dreamstalker and his army of Dreamons, who overpowered him. For a while, Strange believed that he was too weak against Nightmare and lost his magical powers. He was convinced by Spider-Man that it was just a dream and regained his powers, and with the help of Spider-Man and Iron Fist, they sealed Nightmare in a magic box.
After they defeated him, Doctor Strange thanked Iron Fist and Spider-Man and reminded them to go back to Midtown High school before anyone figured out where they had gone.