For Disney, he voiced Grandpa in the Kick Buttowski: Suburban Daredevil episode "Truth or Daredevil", and Mr. Litwak in the 2012 animated film Wreck-It Ralph and reprises his role in the 2018 sequel Ralph Breaks the Internet. He also played George Denver in the 1989 Touchstone Pictures film Disorganized Crime, Bill Dellinger in Prefontaine, Matt in the 8 Simple Rules episode "Old Flame", and Mayor Thompson in the Handy Manny episode "Great Garage Rescue". He even voiced Hank in Finding Dory and in Disney Infinity: 3.0 Edition.
On April 1, 2016, Ed O'Neill was featured with Andrew Stanton as part of an April Fool's joke. The joke involved deceiving viewers into believing that, Ed O'Neill's character from Finding Dory, Hank, was the oldest and most coveted Pixar Easter Egg in history.