Supersonic Stu busts his grandmother, Supersonic Sue, out of prison; at school, Professor Granville asks Wasabi, who fears public speaking, to sub for an absent teaching assistant.
- Ryan Potter as Hiro Hamada
- Scott Adsit as Baymax
- Génesis Rodríguez as Honey Lemon
- Khary Payton as Wasabi
- Jamie Chung as Go Go Tomago
- Brooks Wheelan as Fred
- Jane Lynch as Supersonic Sue
- Timothy Simons as Supersonic Stu
- John DiMaggio as Roddy Blair
- Jenifer Lewis as Professor Granville
- Alan Tudyk as Alistair Krei
- Nestor Carbonell as Chief Cruz
- Zehra Fazal as Basemax, Student
- Alistair Krei is revealed to be working with the SFPD in capturing Big Hero 6 despite the fact that he does not share the same sentiment about them as Chief Cruz.
- Wasabi begins teaching at SFIT, albeit as a substitute.