Fluffy first appears at the beginning of the movie when Cruella is released from her conviction. Alonzo gives Fluffy to Cruella as a present. She mistakes his growling for "smiling" and names him Fluffy, despite having a lack of fur. He is often seen growling whenever Cruella is around. He also helps Chloe and Dipstick escape from Cruella's mansion later on.
In the final scene, Alonso brings Fluffy to the dog shelter when he delivers Cruella's fortune to Chloe and Kevin.
Fluffy makes an appearance in the video game 102 Dalmatians: Puppies to the Rescue and is voiced by Rob Paulsen.
In the game, the factor of Fluffy being Cruella's dog is never brought up. He first meets the pups in the British Museum, where he asks them to place the many misplaced exhibits back to their proper locations, along with asking for a jelly doughnut, which he later reveals to be for him, since he is hungry. Domino or Oddball then advise him to not eat too many doughnuts.
They later meet up with him in Cruella's toy factory, since he himself got captured by Cruella's toys too. Fortunately, since he is skinny, he was able to squeeze through one of the air holes. He guides the pups through the factory, up to their final confrontation with Cruella.