Outside of Sesame Street, Brill has worked on The Muppet Show pilot The Muppet Show: Sex and Violence, two episodes of the actual Muppet Show, Saturday Night Live, and Dog City, amongst many other Muppet projects. Brill was also the original performer of Janice.
Brill retired from puppeteering in 2014. She also played Lily Marvin in the 1991 Touchstone Pictures film, What About Bob? and voiced Emily Kristal Mayonnaise and Mrs. Perigrew in Disney's Doug and Doug's 1st Movie.