In 1966, Buxton teamed up with Hal Seeger in the animated cartoon series Batfink, providing the voice for the title character in all 100 episodes, as well as its recurring villain Hugo A-Go-Go. He also had movie roles in What's Up, Tiger Lily? and Overboard.
He served as a story editor for the comedy anthology series Love, American Style, in addition to writing and directing episodes of The Odd Couple, Happy Days, and Mork & Mindy.
Buxton also created, wrote, produced and directed the television series Hot Dog for NBC, which starred Woody Allen, Tom Smothers, Jonathan Winters and Joanne Worley. The series won a Peabody Award in 1970.