Milo, Cavendish, and Dakota travel back to 1965 and inspire the creation of Dr. Zone only to encounter a sinister plot to take over the world.
- "Weird Al" Yankovic as Milo Murphy
- Sabrina Carpenter as Melissa Chase
- Mekai Curtis as Zack Underwood
- Jeff "Swampy" Marsh as Balthazar Cavendish
- Dan Povenmire as Vinnie Dakota/Heinz Doofenshmirtz
- Dee Bradley Baker as Diogee
- Diedrich Bader as Martin Murphy
- Pamela Adlon as Brigette Murphy
- Kate Micucci as Sara Murphy
- Ming-Na Wen as Savannah
- Phil LaMarr as Marcus Underwood
- Jemaine Clement as Orton Mahlson
- Gregory Michael Cipes as Mort
- Heinz Doofenshmirtz, a character from Phineas and Ferb, another show from Dan Povenmire and Jeff "Swampy" Marsh, appears in this episode.