The Grandmother of the Orphans is in charge of the Orphanage were The Orphans leave in Mickey Mouse
She appears in the episode ¡Feliz Cumpleaños! celebrating Mickey Mouse's Birthday. The episode starts with Goofy, Donald Duck, José Carioca, Panchito Pistoles, Minnie Mouse, and Daisy Duck singing to wake up Mickey. When Mickey comes down the sing again and Grandmother of the Orphans, the Orphans, Clarabelle Cow, Horace Horsecollar and an Unnamed Goat join to sing Happy Birthday to Mickey. But then a cloud of spoke comes to town and the she screams Las Piñatas Bandidas!.Then they all hide under the table except Mickey. She then escapes but gets chase by a Bull Piñata along with a citizen dress like a cowboy. When Mickey gets thrown in the cake there is a flashback of the Grandmother of the Orphans, Minnie, Daisy, Goofy, Horace and the Orphans taking out the Cake from the oven laughing. After Mickey defeats the Piñatas the all come out from the shadows tossing Mickey in the air and celebrating the Piñatas defeat.