After the events of the first film, three young women accidentally bring back The Sanderson Sisters to modern day Salem and must figure out how to stop the child-hungry witches from wreaking havoc on the world.
Bette Midler as Winifred Sanderson, the leader of the Sanderson sisters and the main antagonist. She is the eldest and is highly sensitive to people calling her ugly and has a very short temper. Generally the most intelligent of the three sisters, however she is prone to being melodramatic. She has the power of electrokinesis.
Taylor Henderson as Young Winifred Sanderson
Sarah Jessica Parker as Sarah Sanderson, the youngest sister and one of the secondary antagonists. She uses a siren-like ability to lure children to the Sanderson home. She sings a song called "Come Little Children" to lure the children to there so she can suck their lives to become younger. She is not particularly intelligent and she is often prancing around and goofing off. She is the most beautiful of the three which makes her have the tendency to attract boys and men and flirt with them even when the boys she flirts with are underage, making her an Ephebophile.
Juju Brener as Young Sarah Sanderson
Kathy Najimy as Mary Sanderson, the middle sister and second of the secondary antagonists. Often complimenting and comforting Winifred, she constantly seeks her approval. She has the ability to sniff out the presence of children and has a tendency to bark in a Curly Howard-like fashion. She is the most observant of the three.
Nina Kitchen as Young Mary Sanderson
Doug Jones as Billy Butcherson, the ex-boyfriend of Winifred whom she poisoned, in 1693, after she caught him cheating on her with Sarah.
Whitney Peak as Becca, the main protagonist. A loner without many friends and a stepmother she hates, Becca is an aspiring witch who manages to get her hands on a new dark flame candle at the town's magic shop located in the Sanderson Sisters' cottage.
Belissa Escobedo as Izzy, a confident oddball and the classmate of Becca. Izzy, alongside with Becca, mistakenly summons the Sanderson Sisters on Halloween night leading to chaos in the town.
Lilia Buckingham as Cassie, a popular girl at Becca and Izzy’s school, daughter of the mayor, and a bully of Becca's. However, when Becca accidentally brought back the Sanderson Sisters, she teamed up with the latter in order to stop the child-eating witches.
Froy Gutierrez as Sam, a classmate of Becca and magician who works at Giles' magic shoppe who has a crush on Becca.
In October 2019, a sequel was announced to be in development as a Disney+ exclusive film, with a screenplay written by Jen D'Angelo. Shortly after the report Midler, Parker, and Najimy all confirmed their interest in reprising their roles. In March 2020, Adam Shankman was signed on to direct, but in April 2021, Anne Fletcher took over to direct. On May 14, 2021, Birch teased her reprised role from her Twitter post say "2022 will be Mah-velous". On May 20, 2021, Midler confirmed it will release in Fall 2022. On September 1, 2021, cinematographer Elliot Davis signed in to the production and said they will begin on October 4, 2021 and wrap before new year 2022.