Nipp made his debut in the 1929 animated short The Opry House, in which he posed as a snake for a snake-charming act—continuing to smoke his pipe all the while. Nipp's other two appearances in animation also came in 1929, with When the Cat's Away and The Karnival Kid. The latter film introduced Nipp's habit of physically abusing Mickey, here by stretching out Mickey's nose to a ridiculous length.
Kat Nipp reappeared in a 1931 sequence of the Mickey Mouse newspaper comic strip, "Mickey Mouse vs. Kat Nipp". When Mickey starts intruding near Kat Nipp's house, Kat Nipp retaliates by continually tying Mickey's tail in knots. Mickey vows to not untie said knots until he gets even with Kat Nipp. Kat Nipp was also used in the strips produced in Britain for the Mickey Mouse Annual. However, the character quickly faded away and has made only a handful of appearances in comics since the mid-1930s.