Osbourne played an alternate version of Dorothy Gale in the extended version of the 2005 musical telefilm, The Muppets' Wizard of Oz. She also hosted the second Phineas and Ferb cliptastic countdown episode. She even did the voice of Hildy Gloom in the Disney XD animated series, The 7D, which became her debut in voice acting an animated character.
- Originally Kelly Osbourne was considered for the role of Anna Coleman in the 2003 Disney film, Freaky Friday. But after she backed out, Lindsay Lohan was cast instead.