When Caine was a child, the Princess and heir to the throne of Corona was kidnapped and the King ordered the guards to arrest all the criminals in the kingdom, as he believed that one of them had something to do with his daughter's kidnapping. One of the criminals was a petty thief, Caine's father. Caine was enraged with her father's arrest as he had nothing to do with the Lost Princess' kidnapping and spent the rest of his life in prison until he passed away.
Over the years, Caine became "Lady Caine", the leader of a pirate gang and well known in the thieving and crime community - as Eugene knew who she was and has many criminals willing to serve her.
Lady Caine bided her time until the opportunity to exact her revenge presented itself in the form of Rapunzel's coronation, in which she infiltrated by disguising herself as the "Duchess of Quintonia". On the day of the coronation, Caine made her way to the castle's dungeon so she could free her crew of criminals. When they made themselves known, the crew captured a hand full of nobles and Lady Caine told Rapunzel what her father did to her before she ordered her men to take the King away as Lady Caine wanted King Frederic and the other captured nobles to know what it is like to be locked up and taken away from their families.
Rapunzel, however, wasn't going to let Caine or her crew take her father away, so after she used her long hair to free the captives. Rapunzel, with the help of Eugene and Cassandra battled with the gang of criminals. Lady Caine fought against Cassandra. With her crew defeated and running out of options, Lady Caine grabbed the only weapon that she could get her hands on, which was used to lock the door and keep the guards out; when Caine realized her mistake it was already too late. She and the rest of her crew were arrested for their past and recent crimes and were brought back to the dungeon to serve their sentence.
In "Max's Enemy", Caine is shown to still be in prison, though her connections in the criminal underworld would act as her means of escaping unnoticed; she enlisted the thief, Dwayne, and her horse, Axel, to infiltrate the castle and break her out. The two succeeded in the mission almost without notice, but Maximus eventually caught onto the scheme, as did Rapunzel. Together, the two were able to apprehend Caine and Dwayne, as well as Axel.
In "Max and Eugene in Peril on the High Seas", she and many other bad guys previously encountered by the heroes took over the prison barge they were on. However their plan was foiled again and they were locked up again.
In "Plus Est En Vous", she is surprisingly seen amongst Rapunzel's loved ones and the people of Corona as they sing about living happily ever after.
- In some way, Mother Gothel, the main antagonist of Tangled, is indirectly responsible of Lady Caine's descent into villainy, as if she hadn't kidnapped Rapunzel back when she was a baby, King Frederic wouldn't have ordered the arrest of all criminals in Corona and thus Caine's father wouldn't have spent the rest of his life in prison, causing Caine to become evil.
- Her motivation of desiring vengeance on Rapunzel and King Frederic for the loss of her father is shared by Varian.
- She is so similar to General Lunaris from Ducktales (2017) as she loses her father.