Lady Eboshi is the main antagonist of the 1997 Studio Ghibli film Princess Mononoke (Although, some could argue the Monk Jigo is the bad guy whom she is working for). She was voiced by Yūko Tanaka in the original version and Minnie Driver in the English dub.
While she is the closest thing the movie has to the main antagonist, she is not really a villain. She is still likable and is well aware of the consequences of war. She just wants to create peace amongst the other humans. She doesn't want to harm the forest animals but has to hunt down the spirit god.