Chief Cruz and the police get the upper hand in their battle with both villains and Big Hero 6 when they begin using Buddy Guardians, powerful new robots produced by Krei Tech.
- Ryan Potter as Hiro Hamada
- Scott Adsit as Baymax
- Génesis Rodríguez as Honey Lemon
- Khary Payton as Wasabi
- Jamie Chung as Go Go Tomago
- Brooks Wheelan as Fred
- Nestor Carbonell as Chief Cruz
- John DiMaggio as Roddy Blair
- Isabella Gomez as Megan Cruz
- John Michael Higgins as Mini-Max
- Eric Bauza as Buddy Guardians, Detective Cato
- Zehra Fazal as Basemax, Officer Flynn
- Jenifer Lewis as Professor Granville
- Lucas Neff as Noodle Burger Boy, Police Officer
- Andy Richter as Globby
- Christy Carlson Romano as Trina
- Maya Rudolph as Aunt Cass
- Horatio Sanz as El Fuego
- Laura Silverman as Judy
- Alan Tudyk as Alistair Krei
- Chief Cruz finally realizes the error of his ways and learns Hiro and his friends are Big Hero 6.
- Karmi makes her first physical appearance since "City of Monsters", although she doesn't speak.
- This is the first episode since Season 1 finale "Countdown to Catastrophe" to have its title appear onscreen.
- Honey Lemon, Go Go and Wasabi graduate SFIT.
- Wasabi's car gets thrown into the bottom of the bay again.
- Megan's full name and birthday are revealed in the episode.
- Trina claims that she could not find Obake, suggesting that he is gone for good.