He was portrayed by Juan Carlos Vellido.
Lesaro is described as a ruthless lieutenant of Captain Salazar's undead crew. When the rest of Salazar's crew was killed during an explosion, he was resurrected upon the discovery of the Trident, seeking revenge to kill Jack Sparrow.
Lesaro was the most loyal officer in Armando Salazar's crew, following his captain in his numerous pirate-hunting expeditions. After a battle against ten pirate ships, he informed his captian of the surrender of the pirates, but Salazar ordered their death.
Lesaro's loyalty eventually cost him his life when their ship sailed into the Devil's Triangle where the entire crew was killed in an explosion. However, Lesaro was resurrected by the supernatural powers of the Triangle with his crewmates as the undead. Hungry for revenge, the Spanish escaped from the Triangle and set out on a blind mission of vengeance to find the legendary Trident of Poseidon to kill the man they blamed for their fate - Captain Jack Sparrow. He helped his captain in his quest for the Trident, and regained his human form after its destruction. As he, along with Salazar and the rest of the crew realized that the walls of water were being closed in around them, they all attempted to reach the anchor, their only way out of the depths of the ocean. Salazar and about two other crew members were able to make it aboard, leaving Lesaro the the remaining crew members to be devoured by the sea.
- Lesaro's actor, Juan Carlos Vellido, previously portrayed an unnamed Spanish sea captain in the fourth film.