Cloak and Dagger - Appears alongside Daredevil during the magnetic blackout in "Tolerance is Extinction".
Daredevil - Appears during the magnetic blackout while helping Cloak and Dagger take out some criminals.
Doctor Strange - Seen in "Tolerance is Extinction pt.2" using his powers to perform surgery during the magnetic blackout.
Peter Parker/Spider-Man - Appears in "Tolerance is Extinction pt.1/3". In part one, he witnesses the Magneto blackout as he swings through the city and is later seen with Mary Jane in part three as they watch the news of Asteroid M on a collision course with Earth.
Tony Stark/Iron Man - Seen fighting off the Prime Sentinels alongside Captain America as they protect President Kelly.
Mistique - While her appearance in the show has yet to be confirmed, Mystique does appear in the show's intro. She is also mentioned by Nightcrawler in "Tolerance is Extinction".
Ronan the Accuser (Todd Haberkorn) - Ronan appears in "Lifedeath Pt. 2" where he, among several other Kree are easily defeated by Deathbird, Gladiator and the rest of their legion.
Baron Zemo
Other characters[]
Thaddeus Ross (Mike McGill) - First appears in "Bright Eyes" when Rogue attacks a military base searching for Henry Gyrich.
Dora Milaje - They appear alongside Black Panther during the Magneto blackout.
Mary Jane Watson - Seen with Peter Parker in "Tolerance is Extinction pt.3". She is seen watching the news of Asteroid M on a collision course with Earth.
Mary Jane's appearance in "Tolerance is Extinction" confirms that she and Spider-Man from Spider-Man: The Animated Series reunited and returned to their original Earth. For twenty-six years, the fate of Spider-Man and Mary Jane remained unresolved after the show was cancelled on a cliffhanger.
Show-runner John Semper revealed that, if he had continued the show, Mary Jane would have been found in a Colonial England reality.