Following the structure of Main Street, there is a Train Station at the southernmost tip with the Hub lying at the end of the street. On the right side of the street is a Museum, Horace Horsecollar's Detective Agency and the Mean Street Cinema. On the left side is City Hall, the Firehouse (complete with Walt Disney's apartment), the Emporium, the Ice Cream Parlor and the Penny Arcade. In the center of the hub is an altered version of the Partners statue, with Oswald taking Mickey's place.
In Epic Mickey 2, Mean Street has additional places to visit. The southern half has an Observatory, a Haberdashery, and a path leading to Seth's flower bed. The northern half has a Camera Shop, the Pin Trading Company, and the D.E.C. leading to OsTown.