She and the rest of the Inhuman Royal Family are mind-controlled by Maximus where she is used to declare war on S.H.I.E.L.D. Once Maximus' crown is removed by Spider-Man, Medusa and the rest of the Inhuman Royal Family are freed from his control. Medusa accompanied the rest of the Inhuman Royal Family when they confront Spider-Man and Triton outside the abandoned city of Atarog. When Spider-Man begged forgiveness for trespassing while explaining why they did that, Medusa interpreted for Black Bolt stating that they are here to give them a ride back to the Triskelion while thanking them for protecting Atarog.
Medusa appears with Black Bolt, Gorgon, Karnak, and Lockjaw at the time when an Inhuman ship carrying Seeker and the Alpha Primitives crashes into the mountains near Maple Falls. During the Avengers' fight with the Inhumans, Falcon engaged with Medusa. When Inferno hatches from his Terrigen cocoon, the Avengers and the Inhumans had to work together to stop Inferno. In the episode "The Inhuman Condition", Medusa is among the Inhumans that are captured by Ultron. She is later freed by the Avengers.
