She is among the Inhumans that get affected by a plague that causes crystals to grow on their body. Medusa is freed from her stasis by Star-Lord when the Guardians of the Galaxy are brought to Attilan by Lockjaw. She helps the Guardians of the Galaxy when Maximus the Mad uses his mind-control technology on Black Bolt, and when Ronan the Accuser plans to destroy Attilan. Once those threats are thwarted and the plague is eliminated, Medusa thanks the Guardians of the Galaxy on Black Bolt's behalf. Medusa helps the Guardians of the Galaxy when Maximus tricks his way out of his imprisonment.
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