For Disney, he is best known for voicing John Smith in the 1995 Disney animated feature film, Pocahontas, where he also provided the singing voice for the character. However, his younger brother, Donal took over the role in the 1998 direct-to-video sequel Pocahontas II: Journey to a New World. He also played Tom Mullen in the 1996 Touchstone Pictures film, Ransom, and Rev. Graham Hess, in the 2002 Touchstone Pictures film Signs. He also directed Apocalypto.
- He was considered for the role of Woody in Toy Story. However, Tom Hanks was cast at the end.
- Mel Gibson was originally considered for the role of Ego in Guardians of the Galaxy Vol. 2, but at the end, Kurt Russell was cast instead.
- He was approached for the role of Odin in Thor, but turned it down, in the end, the role went to Anthony Hopkins.