"Mickey and the Culture Clash" is the fifty-second and final episode of House of Mouse, originally aired on Toon Disney's New For You Show! on October 24, 2003.
Mickey thinks that Minnie is looking for a more sophisticated boyfriend, and Mortimer offers to "help." At the end of the episode, they find out it was Mortimer Mouse looking for a new pal.
- This was the final episode of the series to be released before the late Rod Roddy's death a few days after it was aired.
- This is Mortimer's final appearance in the House of Mouse, as well as the final appearances of everyone else in the series.
- Donald and Daisy do not appear in this episode.
- Two appearances of Ariel appeared in the background of this episode when Minnie sees Mickey painting.