Moon Knight is empowered by Khonshu, the Egyptian god of the Moon. This gives him superhuman strength whenever there's a full moon. Besides that, he is an expert at boxing and martial arts and a great combat strategist and uses a wide variety of weapons in his fight against crime, such as bolas, nunchakus, shurikens, boomerangs, tranquilizer darts, a grappling hook, and a staff made of Vibranium.
He makes a cameo in the episode "Avengers World" among the heroes the Avengers planned to recruit in their expansion program. Moon Knight fully appears in the episode "Beyond" where the pyramid he is guarding ends up in the Battleworld domain of Egyptia. When Captain America and Black Widow enter the pyramid and reunite with Iron Man, they fight a mind-controlled Moon Knight and an army of sand-powered mummies to claim a certain orb that he is guarding. After a lengthy battle, Iron Man destroys the device controlling Moon Knight as he helps to finish off the remaining mummies. When Captain America thanks him for his help and states that they would need more soldiers in battle, Moon Knight states that he has to keep the evils locked in the pyramid from being freed. Before leaving with Iron Man and Black Widow, Captain America states that the offer still stands when he is ready.
Moon Knight makes a guest appearance in the show. This version is shown to follow the advice of the Moon, but there is no mentioning of Khonshu. He is first seen chasing after Frances Beck where Spider-Man saves her while house-sitting for Doctor Strange. After figuring out that Frances Beck is the daughter of Mysterio and recalling Doctor Strange's "The Enemy of My Enemy is My Friend" quote, Spider-Man works with Moon Knight in order to take out the female Mysterio. Using a special wand from a restricted room in the Sanctum Sanctorum at the Moon's advice, Moon Knight impales the Mysterio helmet with it. After Spider-Man extracts Quentin Beck and Frances Beck from the helmet before they are doomed, Moon Knight joins Spider-Man, Aunt May, Quentin Beck, and Frances Beck into having dinner. In the final scene, Moon Knight cracks a comment about Spider-Man talking to people who aren't there just like he cracked comments about Moon Knight talking to the Moon.
- Avengers Assemble and Ultimate Spider-Man mark the first animated appearances of Moon Knight.
- In the episode of Ultimate Spider-Man, Moon Knight said "may the moon be with you" is a quote reference to Star Wars "may the force be with you".
Avengers Assemble and Ultimate Spider-Man