Moon Knight is empowered by Khonshu, the Egyptian god of the Moon. This gives him superhuman strength whenever there's a full moon. Besides that, he is an expert at boxing and martial arts and a great combat strategist, and uses a wide variety of weapons in his fight against crime, such as bolas, nunchakus, shurikens, boomerangs, tranquilizer darts, a grapping hook, and a staff made of Vibranium.
Iron Man locates Moon Knight via J.A.R.V.I.S., where he appeared to be operating in Egypt.
Moon Knight makes a guest appearance in the show. This version is shown to follow the advice of the Moon, but there is no mentioning of Khonshu. He is first seen chasing after Frances Beck where Spider-Man saves her while house-sitting for Doctor Strange. After figuring out that Frances Beck is the daughter of Mysterio and recalling Doctor Strange's "The Enemy of My Enemy is My Friend" quote, Spider-Man works with Moon Knight in order to take out the female Mysterio. Using a special wand from a restricted room in the Sanctum Sanctorum at the Moon's advice, Moon Knight impales the Mysterio helmet with it. After Spider-Man extracts Quentin Beck and Frances Beck from the helmet before they are doomed, Moon Knight joins Spider-Man, Aunt May, Quentin Beck, and Frances Beck into having dinner. In the final scene, Moon Knight cracks a comment about Spider-Man talking to people who aren't there just like he cracked comments about Moon Knight talking to the Moon.
- Avengers Assembe and Ultimate Spider-Man mark the first animated appearances of Moon Knight.