Reed first appears helping Henry Pym analyze Princess Ravonna, seeking a way to save her.
When the Avengers Iron Man and Wasp come to visit at the Baxter Building, Doctor Doom kidnaps Sue and Wasp. The Avengers and Fantastic Four go to Latveria to rescue them, and after a fight Doom just lets them go. What Reed and the others don't know is that Doom has discovered Sue isn't the real one, but a Skrull imposter.
Reed and the rest of the Fantastic Four almost fell victims of the Skrull Sue imposter, but the real Sue somehow saves them.
Some time later, he was part of the Avengers' expanded team against Galactus.
- Mr. Fantastic marks the first time Dee Bradley Baker voiced a Marvel character since Marvel was purchased by Disney, he had previously voiced Young Keene Marlow in the 1990s Spiderman tv series.
- As a long time fan of the comics John Krasinski still expressed interest in portraying Reed Richards / Mister Fantastic in the upcoming film. He also hoped his wife Emily Blunt would also portray Susan Storm / Invisible Woman in the film.