"Mr. Whiskers's First Friend" is the first segment of the first episode of Brandy & Mr. Whiskers.
Goofy-bunny Mr. Whiskers meets prissy-pooch Brandy Harrington within a cargo hold of a plane. When Whiskers mistakenly opens the hatch door, the pair is dropped into the Amazon Rainforest with no way home. Desperate and angry, Brandy makes a deal with the dictatorial lizard Gaspar: a way back to civilization in exchange for Mr. Whiskers as his dinner. In the end, she loses her way home, but truly gains a friendship with Lola Boa and Mr. Whiskers.
- When Brandy and Mr. Whiskers fall out of the plane, it is a parody of the 1941 Bugs Bunny cartoon, The Heckling Hare.