Nebula was created by Roger Stern and John Buscema.
Like Ebony Maw, Proxima Midnight, Corvus Glaive, Cull Obsidian, and Gamora, Nebula was taken from her homeworld, an unnamed planet home to the Luphomoids, when Thanos massacred half of its population.
Nebula appears to be the photo-negative of her sister: cruel, evil, and considered by men as strong as the Ravagers as the galaxy's biggest sadist. Despite turning against Thanos, she was still a criminal whose primary focus was what supported her in the moment (not unlike Loki). However, she has become more mellow and heroic in recent years, showing a selfless and heroic side as she willingly participates in the Infinity War.
Nebula is intelligent, but she appears not to be very good at creating strategies. For instance, she deserted Ronan when he was (currently) her only hope against Thanos, and she damaged her own ship attempting to shoot down Gamora.
Prior to the Infinity War, Nebula appeared to be very disloyal, as she ultimately betrays everyone and works for her own ends. Her exploits after the Battle of Xandar have been a journey of renewal for her as she begins to determine her own ideas of good and evil.
Nebula is a tall, slender, athletic, curvy, and beautiful blue-skinned humanoid cyborg woman with an oval head and black eyes. She is also bald (whether this is natural for Luphomoids, or the result of her cybernetic implants, is unclear). She has a robotic prosthetic arm and metallic implants around her left eye. She is clad in a black-and-purple jumpsuit that allows her complete freedom of movement while still keeping her completely modest. Her gloves, belt, and boots are all black and appear to be made of plastic. Following her help in Taserface's takeover of the Ravagers, Nebula changes her costume to a red leather one similar to that worn by the said gang. Her cybernetics, whilst given to her as a punishment, have proved to be an advantage: she can fix her body if she is injured using her cybernetics, as shown when Drax blasted her with the Hadron Enforcer, which was capable of destroying entire moons, and she plummeted an undisclosed amount of feet and rose to fight and nearly overpower Gamora moments after she landed.
Nebula is first seen aboard Ronan the Accuser's starship, asking to be put on the mission to retrieve the Orb, but shows some hostility when Gamora is chosen in her place. They tracked her to the Kyln, but as Gamora had already escaped, Nebula and Ronan massacred its residents together.
She is later seen in the raid on Knowhere, and chases Gamora's pod into the outer atmosphere where she destroys the pod. When Ronan decides to betray Thanos, Nebula asks him if he's going to kill his father, Ronan thinks she is going to oppose but instead she is allied with him promising if he kills Thanos she would help him to destroy thousands of planets.
Once the Guardians enter on Ronan's ship in Xandar, Nebula battles Gamora but escapes on a space pod, realizing that Ronan has lost the battle and has gone insane with power.
Nebula proceeds to live as a criminal until she is captured and placed in the custody of the Guardians of the Galaxy. Thanks to Baby Groot, she eventually escapes and makes a deal with Taserface. Afterwards, she vows to kill Gamora and proceed to kill Thanos. She finds Gamora on Ego's Planet and attacks her, but after Gamora shows her mercy and saves her life, the two create an unlikely and temporary alliance against Ego after Nebula reveals that all she ever wanted was to have a sister. Before Nebula leaves to go after Thanos, Gamora reconciles with her by giving her a hug and telling her that she will always be her sister.
Nebula is tortured by Thanos as her father wants to force Gamora to relent and tell him where the Soul Stone can be found. Nebula later escapes and helps the Avengers and Guardians fight him, but they ultimately lose. Nebula realizes what has happened when all the Guardians turn to dust except for Rocket.
Nebula joins the rest of the heroes in travelling back in time to retrieve the Infinity Stones and the Infinity Gauntlet. They succeeded, and Hulk/Bruce Banner uses the Infinity Gauntlet to undo the snap and bring everyone back to life. However, the heroes are noticed by the 2014 versions of Thanos and Nebula, who travel forwards in time to 2023 to attack Avengers Headquarters in retaliation. 2023 Nebula joins the fight alongside the other heroes. 2014 Nebula and Thanos are killed, and 2023 Nebula joins Rocket Racoon, Thor, Drax, Mantis and Star-Lord in the new incarnation of the Guardians of the Galaxy.
Nebula appears in "What If... T'Challa Became a Star-Lord?". Due to Thanos giving up his plan of wiping out half of life's population, she's never fully robotized and have a very good relationship with her adoptive father. She meets up with Star-Lord and the Ravagers at Contraxia to plan a heist to steal the Embers of Genesis from the Collector.
- Gal Gadot revealed that she was up for the role of Nebula, before it went to Karen Gillan.
- Zoe Saldana (Gamora's actress) has said that the relationship between Gamora and Nebula is her favorite aspect of Guardians of the Galaxy, and hits close to home for her, having sisters of her own.
- Nebula understands quantum time travel just as well as Professor Hulk; immediately agreeing with him that Scott and Rhodes belief in time travel being like the movies is wrong.