Many of the film's scenes take place in Philadelphia, where Benjamin Gates searches for clues to a lost treasure, some of which are found in Independence Hall, The Franklin Institute, and Trinity Church.
"Invincible" follows the true story of Vince Papale, a wide receiver and special teams of the Philadelphia Eagles from 1976-1978.
The film takes place in Philadelphia and tells the story of David Dunn, a security guard who discovers that he is a superhero.
M. Night Shyamalan's thriller follows a Philadelphia boy, Cole Sear who can see and speak to the dead, and Dr. Malcolm Crowe, a child psychologist who tries to help Cole with his condition.
The short film follows the story of a mouse named Amos who befriends Benjamin Franklin and aids him through his publishings, inventions, and political career. Amos also assists Thomas Jefferson in drafting the Declaration of Independence.
One of the courses in the "Motor Way Mania" section takes place in Philadelphia, which is set mostly on a harbor for a ship. The player must dodge hanging crates being lowered to the ground, and then the action then moves into the docked ship.
While Philadelphia itself is not represented in the Disney Parks, several historical figures associated with the city are featured in several attractions throughout the parks.
- Philadelphia was the second city in General and the United States to house the traveling Pixar exhibition, The Science Behind Pixar.
- Several issues of Marvel comics feature some of the superheroes visiting Philadelphia for various reasons. In 2012, Flash Thompson/Venom moved to the city in Venom #27.1 to escape the symbiote from taking over his body again.
- Despite the Silence Dogood letters being on display at the Franklin Institute in the film National Treasure, they are not featured at the museum in Real Life.