It is first seen as the place where Pongo and Roger Radcliffe meet Perdita and Anita Radcliffe. It was also here, when the Dalmatians puppies are dognapped, Pongo and Perdita alert others dogs using the "Twilight Bark", on top of "Primrose Hill", where the Dalmatians later meet up, with Danny, when he has news on their puppies.
Regents Parks first appears when there is an audition where one dog will be a guest on Thunderbolt’s show. This is where the show is shot, and where Patch and Thunderbolt hang out.
"Regents Park" is the first level of 102 Dalmatians: Puppies to the Rescue, where the player Dalmatian needs to work their way through the Park. Jasper patrols the park however, but the Dalmatians are able to handle them by causing him to accidentally attack a beehive. The Dalmatians also meet up with Waddlesworth, who explains what is happening, and also help Fidget, a squirrel, who helps the Dalmatians, find his nut.
"Regents Park" is also one of the stages that the player can choose to play in Disney TH!NK Fast. The stage shows Cruella in her car, driving about in the background, along with Horace and Jasper, in their truck. If the player scores high in this stage, they win a Dalmatian theme top hat, as an optional attire.
- While Regents Park is used in One Hundred and One Dalmatians, along with being where the original novel is set, in the live-action version 101 Dalmatians, the park used is St. James, near Buckingham Palace.