The Sacred Timeline is the name of the conglomerate of timelines in the Marvel Cinematic Universe. It consists of the timelines of the Multiverse which were isolated by He Who Remains after the Multiversal War.
The timelines were reorganized into a single timeline to prevent the Variants of Kang to dominate the Multiverse. To avoid the return of the Kang Variants, He Who Remains created the Time Variance Authority, an organization that prunes growing branches and Variants. Thus, the TVA keeps the proper flow of time according to the path determined by He Who Remains.
After Sylvie killed He Who Remains, the Sacred Timeline branched off irreversibly.