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The movie will feature an older Nick Szalinski following in Wayne's footsteps as he continues Wayne's size-changing experiments while they both deal with Diane's death. Nick now has two children, Theo, who has a gloomy disposition and is sensitive about his weight, and Maddie, who hosts a YouTube show where she showcases Nick's inventions. His sister, Amy, will also return for this movie.[1][2][3][4][5]
The movie marks Rick Moranis' return to acting after several years of retirement.
Diane Szalinski's death in this film is very likely out of respect of Marcia Strassman, who originally played the character in the first two films and died in 2014.