Sista Spice is a character and the main antagonist from the Proud Family season 2 episode "Penny Potter". She is Suga Mama's older sister, Oscar and Bobby's maternal aunt and Penny, BeBe, and CeCe's paternal great aunt.
She is claimed by Suga Mama that her parents seem to have more attention and caring for her because of her beauty and mental powers and that they didn't even know Suga Mama existed. As Sista Spice arrives in town, she was glad everyone was happy to see her -- except her sister. She sent her flying out of the Proud family house over to Bobby's house. Later, she entertains her great-grandniece Penny and her friends with her powers, she chooses Zoey as her kin and teaches her how to focus, using her own powers to make it seem like Zoey is psychic. After that, when her show is being held outside in the Proud Snax parking lot since she was rejected by Wizard Kelly from his arena earlier, she attempts to swindle Oscar out of money but was foiled by Wizard Kelly and Suga Mama.
- Despite her craftiness, Spice did seem to be a good aunt to Oscar, who was regularly ignored by Sugar and even Bobby.