- Danny Pudi as Huey Duck
- Kate Micucci as Webby Vanderquack
- Lin-Manuel Miranda as Fenton Crackshell-Cabrera
- Jameela Jamil as Gandra Dee
- Beck Bennett as Launchpad McQuack
- Jim Rash as Gyro Gearloose
- Selenis Leyva as Officer Cabrera
- Josh Brener as Mark Beaks/Mega Beaks
- Tom Kenny as Dr. Atmoz
- Kari Wahlgren as Roxanne Featherly
- April Winchell as Security System
- On the news, a reporter is heard saying "the day is saved thanks to Gizmo Duck", an obvious reference to Cartoon Network's The Powerpuff Girls where the narrator closes every episode with the same line with the girls in the closing shot.
- Tom Kenny, the voice of Dr. Atmoz, was also the newscaster who said "the day is saved thanks to Gizmo Duck", the same way he used to when he was narrator for The Powerpuff Girls.
- Fenton wore an outfit that used to belong to his father. It was similar to James "Sonny" Crockett from the 1984 TV show "Miami Vice".
- Fenton and Gandra's date is a tribute to Lady and the Tramp.
- When Fenton and Gandra talk about science they say "crackpot" at the same time. This may be a nod to the scene in "Aladdin" where Aladdin and Jasmine say "Trapped" at the same time.
- Mark Beaks turning into a huge, muscular monster (and his follow-up line "You're all incredibly dead!") is a reference to the Incredible Hulk.
- However, Mark Beaks' ability to enhance superhuman strength using stolen Gyro-Tech and Gandra's nanites could also be a reference to the DC Comics villain, Bane using Venom to enhance his superhuman strength during his battle against Batman as well. Even some of his fighting skills match Bane's fighting skills at some point.
- The scene where Mega Beaks carries Huey and Webby up to the top of his company building, Waddle is a reference to the 1933 movie, King Kong where the titular character carries Ann Darrow up to the top of the Empire State Building.
- This is the third episode to use a different tune in the end credits rather than an instrumental version of the theme song. The other episodes to do so, are "Who is Gizmoduck?!" and "Last Christmas!".
- The villain GizmoDuck battles in the beginning of the episode resembles Dr. Heinz Doofenshmirtz. His ability to control weather seems to be based on DC Comics villain Weather Wizard who has fought the Flash using weather control.
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