Theodore Roosevelt appears in the episode Tarzan and the Rough Rider where he visits the jungle on safari and runs afoul of kidnappers. At first he does not impress Tarzan who does not se him as being a worthy leader, but manages to prove otherwise later. Here, he is voiced by Stephen Root.
Theodore Roosevelt appears in several chapters of the storyline. In The Buckaroo of the Badlands, set before his presidency in the year 1882, he befriends Scrooge McDuck and helps him defeat a group of cattle rustlers. Years later, in the chapter The Invader of Fort Duckburg, Roosevelt is called in by the Junior Woodchucks to reclaim the ruins of Fort Duckburg, which Scrooge McDuck purchased to build the Money Bin. Bringing in the army and after a comical battle, Theodore recognizes his old friend Scrooge and the two stop the fighting and get reacquainted while having a campfire dinner.
Theodore Roosevelt appears in The Hall of Presidents and The American Adventure. In the latter, he appears in a scene focusing on the establishment of the National Parks with John Muir beginning with Yosemite