He appeared in the episode; "Hercules and the Return of Typhon". While battling Echidna, Typhon's wife, Hercules accidentally freed his father's greatest nightmare and Typhon prepared for a rematch by spending "quality time" with Echidna and baby Ladon. When Zeus and Hercules reappeared, Typhon throttled his enemy and nearly succeeded when Hera once more intervened and threw a lightning bolt into his nostril, forcing all three monsters to flee. When they discover that Hera and Zeus were working together, Echidna and Typhon attempted to get Homer to fix the facts.
In "Hercules and the Long Nightmare", Phantasos, the god of dreams and younger brother of Morpheus, served as main antagonist in the episode. He spreads his own blanket of nightmares over the world, causing Hercules and Phil and the rest of Greece to have bad dreams. Phantasos takes the form of Typhon during his final stage of his battle with Hercules before being pulled back into reality.
- Typhon's voice actor was cast with TV personality Regis Philbin. Typhon's wife, Echidna, was cast with Philbin's then-co-star Kathie Lee Gifford.
- In Greek Myth, Typhon wasn't actually a Titan. He was created by Gaia to avenge the Titans.