Preisner is best known for the music composed for the films directed by fellow Pole Krzysztof Kieślowski. His Song for the Unification of Europe, based on the Greek text of 1 Corinthians 13, is attributed to a character in Kieślowski's Three Colors: Blue and plays a dominating role in the story. His music for Three Colors: Red includes a setting of Polish and French versions of a poem by Wisława Szymborska, a Polish Nobel Prize-winning poet.
He working as composer to American, European and Polish movies.
He makes a score to two Touchstone Pictures movies.